Five traditionally used antidiabetic native medicinal plants of Mauritius, namely, Stillingia lineata (SL), Faujasiopsis flexuosa (FF),\nErythroxylum laurifolium (EL), Elaeodendron orientale (EO), and Antidesma madagascariensis (AM), were studied for possible ??-\namylase and ??-glucosidase inhibitory property, glucose entrapment, and amylolysis kinetics in vitro. Only methanolic extracts of\nEL, EO, andAM(7472.92�±5.99, 1745.58�±31.66, and 2222.96�±13.69 ??g/mL, resp.) were found to significantly (?? < 0.05) inhibit ?-\namylase and were comparable to acarbose. EL, EO, AM, and SL extracts (5000 ??g/mL) were found to significantly (?? < 0.05) inhibit\n??-glucosidase (between 87.41 �± 3.31 and 96.87 �± 1.37% inhibition). Enzyme kinetic studies showed an uncompetitive and mixed\ntype of inhibition. Extracts showed significant (?? < 0.05) glucose entrapment capacities (8 to 29% glucose diffusion retardation\nindex (GDRI)), with SL being more active (29% GDRI) and showing concentration-dependent activity (29, 26, 21, 14, and 5%,\nresp.). Amylolysis kinetic studies showed that methanolic extracts were more potent inhibitors of ?-amylase compared to aqueous\nextracts and possessed glucose entrapment properties. Our findings tend to provide justification for the hypoglycaemic action of\nthesemedicinal plants which has opened novel avenues for the development of new phytopharmaceuticals geared towards diabetes\nmanagement.
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